| Dave Mustaine - vocal, guitar | 1983-2002, 2003- |
| Gregory L. Handevidt - guitar | 1983-1984 |
| Kerry King - guitar | 1984 |
| Chris Poland - guitar | 1984-1985, 1986-1987, 2004 |
| Mike Albert - guitar | 1985 |
| Jay Reynolds - guitar | 1989-1990 |
| Jeff Young - guitar | 1987-1989 |
| Marty Friedman - guitar | 1990-1999 |
| Al Pitrelli - guitar | 2000-2002 |
| Glen Drover - guitar | 2004-2008 |
| Chris Broderick - guitar | 2008- |
| David "Dave" Ellefson - bass | 1983-2002 |
| Jimmy Sloas - bass | 2004 |
| James MacDonough - bass | 2004-2006 |
| James Lomenzo - bass | 2006-2010 |
| David Ellefson - bass | 2010- |
| Dijon Carruthers - drums | 1983 |
| Lee Rauch - drums | 1983-1984 |
| Gar Samuelson - drums | 1984-1987 |
| Chuck Behler - drums | 1987-1989 |
| Nick Menza - drums | 1989-1998, 2004 |
| Jimmy DeGrasso - drums | 1998-2002 |
| Vinnie Colaiuta - drums | 2004 |
| Shawn Drover - drums | 2004- |
